Cancer genes and blood clots
نویسندگان
چکیده
منابع مشابه
Invadopodia formation in blood clots
Blood clotting specifically supports the metastatic dissemination of malignant cells to the lung. We have recently demonstrated that 2 tumor types that are prone to form lung metastases, renal cell carcinoma and soft tissue sarcoma, share specific adhesive mechanisms that support the invasion and colonization of blood clots in the pulmonary vasculature.
متن کاملA model for the formation and lysis of blood clots.
Both biochemical and mechanical factors have to be taken into account if a meaningful model for the formation, growth, and lysis of clots in flowing blood is to be developed. Most models that are currently in use neglect one or the other of these factors. We have previously reported a model [J Theoret Med 2003;5:183-218] that we believe is a step in this direction, incorporating many of the cru...
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After trauma, the formation of a thrombus is essential to stem bleeding. A cascade of proenzymes, enzymes, and cofactors interact with damaged vessel endothelium to converge on a common pathway with the formation of a fibrin clot. The clot acts as a mechanical plug to prevent bleeding and is vital for normal vascular function. Disturbance of this pathway can be deadly; too little clotting resul...
متن کاملContraction of Blood Clots Is Impaired in Acute Ischemic Stroke.
OBJECTIVE Obstructive thrombi or thrombotic emboli are the pathogenic basis of ischemic stroke. In vitro blood clots and in vivo thrombi can undergo platelet-driven contraction (retraction), resulting in volume shrinkage. Clot contraction can potentially reduce vessel occlusion and improve blood flow past emboli or thrombi. The aim of this work was to examine a potential pathogenic role of clot...
متن کاملLung cancer-related genes in the blood.
Tumor-related genes can be found circulating in the blood of cancer patients. These genes may be derived from circulating cancer cells or from the patient's primary tumor directly by a process referred to as "gene shedding." Selective and sensitive detection of tumor-related genes in the blood of cancer patients has been made possible by the advent of polymerase chain reaction-based technology ...
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ژورنال
عنوان ژورنال: Blood
سال: 2021
ISSN: ['1528-0020', '0006-4971']
DOI: https://doi.org/10.1182/blood.2020009967